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The vaccine itself: Some vaccines have ingredients that can irritate your arm a bit

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This is normal for B12-containing formulations

The Link Between NSAIDs and Oxidative Stress While NSAIDs are widely used to manage pain and inflammation, emerging research suggests that their long-term use may contribute to oxidative stress, a condition in which free radicals overwhelm the body's antioxidant defenses

transient flushing or headache may occur [7]